Prion Protein in Milk
نویسندگان
چکیده
منابع مشابه
Prion Protein in Milk
BACKGROUND Prions are known to cause transmissible spongiform encephalopathies (TSE) after accumulation in the central nervous system. There is increasing evidence that prions are also present in body fluids and that prion infection by blood transmission is possible. The low concentration of the proteinaceous agent in body fluids and its long incubation time complicate epidemiologic analysis an...
متن کاملProgress on Milk Safety in Relation to Prion Protein
Transmissible spongiform encephalopathies (TSEs) belong to prion diseases that are invariably common fatal neurological disorders and affect humans and animals. Prion protein (PrP) was regarded as the only infectious agent inprion diseases and much attention was focused on the safety of PrP in foodstuffs. In this review, theprogress on the safety of milk relation to PrP and transmission route o...
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The chemical nature of prions and the mechanism by which they propagate are now reasonably well understood. In contrast, much less is known about the identity of the toxic prion protein (PrP) species that are responsible for neuronal death, and the cellular pathways that these forms activate. In addition, the normal, physiological function of cellular PrP (PrP(C)) has remained mysterious, hampe...
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The chemical nature of prions and the mechanism by which they propagate are now reasonably well understood. In contrast, much less is known about the identity of the toxic prion protein (PrP) species that are responsible for neuronal death, and the cellular pathways that these forms activate. In addition, the normal, physiological function of cellular PrP (PrPC) has remained mysterious, hamperi...
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Localizing the cellular prion protein (PrPC) in the brain is necessary for understanding the pathogenesis of prion diseases. However, the precise ultrastructural localization of PrPC still remains enigmatic. We performed the first quantitative study of the ultrastructural localization of PrPC in the mouse hippocampus using high-resolution cryoimmunogold electron microscopy. PrPC follows the sta...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2006
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0000071